Shamrock Rovers had been overwhelmed 3-0 at Gent of their Europa Convention League tie on Thursday evening.
The League of Eire facet had been seeking to construct on a goalless draw at dwelling to Swedish membership Djurgardens of their opening Group F tie.
The Belgians, although, proved too robust as objectives from Hugo Cuypers and Vadis Odjidja-Ofoe noticed them 2-0 up inside 18 minutes.
Midfielder Odjidja-Ofoe, who had a spell in England with Norwich, added a 3rd with a curling shot simply after the hour.
Djurgardens beat Norwegian facet Molde 3-2, leaving Shamrock Rovers backside of the group.
Elsewhere, Fiorentina misplaced 3-0 at Istanbul Basaksehir, whereas Scottish membership Hearts gained 2-0 at Latvian facet RFS.
A primary-half penalty from Lawrence Shankland put the Jambos forward, with Alan Forrest sealing victory in stoppage-time to place Hearts second in Group A.
West Ham high Group B with a 100 per cent report after coming from behind to beat Danish facet Silkeborg 3-2.
Kasper Kusk had put the hosts forward early on, earlier than Manuel Lanzini equalised from the penalty spot.
Gianluca Scamacca and a header from Craig Dawson made it 3-1 to the Irons going into half-time, however Soren Tengstedt’s late purpose gave Silkeborg hope.
Within the Europa League, Manchester United gained 2-0 at Sheriff Tiraspol with a first-half purpose from Jadon Sancho and Cristiano Ronaldo’s spot-kick.
Actual Sociedad, who gained at Outdated Trafford final week, sit high of Group E after their 2-1 victory over Omonia Nicosia.
Italian facet Lazio went down 5-1 at Midtjylland in Group F, whereas Feyenoord noticed off Sturm Graz 6-0 at De Kuip with a brace from Iran ahead Alireza Jahanbakhsh.
Bundesliga leaders Union Berlin misplaced 1-0 at Braga, who high Group D. In Group H, French facet Monaco had been overwhelmed 1-0 at dwelling Ferencvaros.
Bodo Glimt battled to a 2-1 win over Zurich, which sees the Norwegians lead Group A, with Arsenal’s tie towards PSV Eindhoven having been postponed due to lack of obtainable police in London in the course of the nationwide interval of mourning following the demise of the Queen.